Impact of acute lymphoblastic leukemia on the microbiome and oral lesions: scoping review

  • Olga Leticia García Rico Clínica de diagnóstico, Laboratorio de Bioquímica, Microbiología y Patología Facultad de Estomatología, Universidad Autónoma de San Luis Potosí. San Luis Potosí, México. https://orcid.org/0000-0002-7573-0062
  • Juan Gerardo Sánchez Medina Clínica de diagnóstico, Laboratorio de Bioquímica, Microbiología y Patología Facultad de Estomatología, Universidad Autónoma de San Luis Potosí. San Luis Potosí, México. https://orcid.org/0000-0002-1588-7850
  • Elizabeth Sánchez Becerra Clínica de diagnóstico, Laboratorio de Bioquímica, Microbiología y Patología Facultad de Estomatología, Universidad Autónoma de San Luis Potosí. San Luis Potosí, México. https://orcid.org/0000-0002-7479-2050
  • Juan Antonio Cepeda Bravo Departamento de Periodoncia Facultad de Estomatología, Universidad Autónoma de San Luis Potosí. San Luis Potosí, México. https://orcid.org/0000-0002-6696-3796
  • Francisco Javier Tejeda Nava Departamento de Imagenología Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México. https://orcid.org/0000-0002-9330-6644
  • Ana Karenina Rocha Viggiano Laboratorio de epigenética, Facultad de Medicina, Universidad Autónoma de San Luis Potosí. San Luis Potosí, México. https://orcid.org/0000-0001-5576-2764
  • Mariana Salgado Bustamante Laboratorio de epigenética, Facultad de Medicina, Universidad Autónoma de San Luis Potosí. San Luis Potosí, México. https://orcid.org/0000-0003-0242-7190
  • Saray Aranda Romo Clínica de diagnóstico, Laboratorio de Bioquímica, Microbiología y Patología Facultad de Estomatología, Universidad Autónoma de San Luis Potosí. San Luis Potosí, México. https://orcid.org/0000-0002-0379-9626
Keywords: microbiota, microbiome, acute lymphoblastic leukemia, oral bacteria, oral lesions, dysbiosis

Abstract

Objective: To describe the existing knowledge about the alterations of the MBO and the presence of LO in patients with ALL. Material and Method: An electronic search was carried out in the PubMed, Scielo, and Academic Google databases, and descriptive, analytical, and observational articles on MBO, LO, and LLA were included. 642 articles were evaluated, duplicate articles, case reports, and those where they only reported changes during or after chemotherapy treatment were eliminated. Results: 10 articles were evaluated and published between 1997 and 2021, 4 articles agreed that the MBO of patients with LLA was found in dysbiosis showing a significant increase in firmicutes, bacillus, and opportunistic bacteria such as Moraxella spp, Klebsiella spp, Pseudomonas spp, Enterobacter spp, Acinetobacter spp, andE. coli, the most frequent LO reported in 5 articles were spontaneous gingival bleeding, gingivitis, and ulcers. Conclusions: The oral cavity of patients with ALL is in dysbiosis and associated OL is identified. It is necessary to establish preventive strategies with a niche-ecological approach to restore the MBO, to reduce the risk of opportunistic infections and other LO during chemotherapy treatment

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Author Biography

Ana Karenina Rocha Viggiano, Laboratorio de epigenética, Facultad de Medicina, Universidad Autónoma de San Luis Potosí. San Luis Potosí, México.

 

 

 

Published
2022-12-27
Section
Review Articles