Caries Dental y Microbiota. Revisión


  • Laura García Castro CD.Esp. Maestrando Odontopediatría Universidad Científica del Sur, Lima-Perú.
  • Gainnina Tello-Guerrero CD.Esp. Maestrando Odontopediatría Universidad Científica del Sur, Lima-Perú.
  • Luciano Álvaro-Ordoñez CD.Esp. Maestrando Odontopediatría Universidad Científica del Sur, Lima-Perú.
  • Guido Perona-Miguel de Priego CD.Esp. Coordinador Maestría Odontopediatría Universidad Científica del Sur, Lima-Perú.



Caries dental, Microbiota, Disbiosis, Streptococcus mutans


Cuando ocurre un desequilibrio en el balance de minerales en contacto con la superficie del esmalte dental y el balance es negativo hacia una pérdida de minerales se produce una degradación de la superficie y subsuperficie, este desequilibrio afecta al diente en su forma, función, sensibilidad y estética, esta alteración va a cambiar el status del microbioma. Investigaciones recientes sobre ADN y ARN relacionados a la lesión de caries han demostrado un ecosistema extraordinariamente diverso donde el conteo del Streptococo Mutans es sólo una muy pequeña fracción de la comunidad bacteriana hallada. Por lo tanto la dirección de prevención y/ó terapias específicas de caries dental no sólo deben estar enfocadas en el Streptococo Mutans porque se sabe que no están presentes en la primera colonización o inicio de la caries dental y se deben buscar estrategias dirigidas a la modulación de las interacciones entre microorganismos para poder tener una adecuada estrategia de prevención tomando como pilar principal a los microorganismos que inician la enfermedad.



Download data is not yet available.


Costalonga M, Herzberg MC. The bucal microbiome and the inmunobiology of periodontal disease and caries.. Immunology letters. 2014;162(2 0 0):22-38. Disponible en :

Rudney JD et al. Proteine relative abundance patterns associated with sucrose induced dysbioses are conserved across taxonomically diverse bucal microcosm biofilm models of dental caries. Microbiome.2015.

:69. Disponible en:

Kianoush N et al. Bacterial profile of dentine caries and the impact of Ph on bacterial population diversity. PLoS ONE.2014.9(3):1-10.

Wade W. The bucal microbiota. En: Nibali L, Henderson B. The human microbiota and chronic disease : dysbiosis as a cause of human pathology. New Jersey. John Wiley & sons. 2016. Pp. 67-76.

Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the bucal cavity. J Clin Microbiol 2005; 43: 5721-32.

Badet C, Thebaud NB. Ecology of lactobacilli in the bucal cavity: a review of literature. Open Microbiol J 2008; 2: 38-48.

Tanner AC, Mathney JM, Kent RL, Chalmers NI, Hughes CV, Loo CY, et al. Cultivable anaerobic microbiota of severe early childhood caries. J Clin Microbiol 2011; 49: 1464-74.

Aas JA, Griffen AL, Dardis SR, Lee AM, Olsen I, Dewhirst FE, et al. Bacteria of dental caries in primary and permanent teeth in children and young adults. J Clin Microbiol 2008; 46: 1407-17.

Simo´n-Soro, A. et al. (2014) Metatranscriptomics reveals active bacterial composition in caries lesions. J. Bucal Microbiol. 6, 25443.

Chen, P.B., Davern, L.B., Katz, J., Eldridge, J.H., and Michalek, S.M. 1996. Host responses induced by coinfection with Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in a murine model.

Bucal Microbiol. Immunol. 11, 274–281.

Nagashima, H., Takao, A., and Maeda, N. 1999. Abscess forming ability of Streptococcus milleri group: synergistic effect with Fusobacterium nucleatum. Microb. Immunol. 43, 207–216.

Ramos, C., Licht, T.R., Sternberg, C., Krogfelt, K.A., and Molin, S. 2001. Monitoring bacterial growth activity in biofilms from laboratory flow chambers, plant rhizosphere, and animal intestine. Methods Enzymol.

, 21–42.

Dalton, T., Dowd, S.E., Wolcott, R.D., Sun, Y., Watters, C., Griswold, J.A., and Rumbaugh, K.P. 2011. An in vivo polymicrobial biofilm wound infection model to study interspecies interactions. PLoS One 6, e27317.

Peters, B.M., Jabra-Rizk, M.A., O’May, G.A., Costerton, J.W., and Shirtliff, M.E. 2012a. Polymicrobial interactions: impact on pathogenesis and human disease. Clin. Microbiol. Rev. 25, 193–213.

Kämmerer, H. 1924. Beitrage zur Bedeutung des Bakteriellen Synergismus Synergismus

Bjornson, H.S. 1982. Bacterial synergy, virulence factors, and host defense mechanisms in the pathogenesis of intraabdominal infections. In Simmons, R.L. (ed.), Topics in intraabdominal surgical infection, pp. 65–78. Appleton-Century-Crofts, Norwalk, CT, USA

Murray, J.L. et al. (2014) Mechanisms of synergy in polymicrobial infections. J. Microbiol. 52, 188–199.

Ramsey, M.M. et al. (2011) Metabolite cross-feeding enhances virulence in a model polymicrobial infection. PLoS Pathog. 7, e1002012.

Doel, J.J. et al. (2005) Evaluation of bacterial nitrate reduction in the human bucal cavity. Eur. J. Bucal Sci. 113, 14–19.

Harriott, M.M. and Noverr, M.C. (2011) Importance of Candida– bacterial polymicrobial biofilms in disease. Trends Microbiol. 19, 557–563.

Pride, D.T. et al. (2012) Evidence of a robust resident bacteriophage population revealed through analysis of the human salivary virome. ISME J. 6, 915–926:

Lim, S.M. et al. (2011) Microbial profile of asymptomatic and symptomatic teeth with primary endodontic infections by pyrosequencing. J. Korean Acad. Conserv. Dent. 36, 498–505.

Xu, J.S. et al. (2014) Effect of emodin on the cariogenic properties of Streptococcus mutans and the development of caries in rats. Exp. Ther. Med. 8, 1308–1312.

Simo´n-Soro, A. et al. (2013) A tissue-dependent hypothesis of dental caries. Caries Res. 47, 591–600.

Cagetti, M.G. et al.The use of probiotic strains in caries prevention: a systematic review. Nutrients 5, 2530–2550 . (2013).

Austin, M. et al.Fecal microbiota transplantation in the treatment of Clostridium difficile infections. Am. J. Med. 127, 479–483. (2014).

Devine, D.A. and Marsh, P.D. Prospects for the development of probiotics and prebiotics for bucal applications. J. Bucal Microbiol. 1, 1(2009).

Hart, T.C. et al. Identification of microbial and proteomic biomarkers in early childhood caries. Int. J. Dent. 2011, 196721. (2011).

Rocas, I.N. and Siqueira, J.F., Jr .Characterization of microbiota of root canal-treated teeth with posttreatment disease. J. Clin. Microbiol. 50, 1721–1724. (2012).

Fejerskov, O. Changing paradigms in concepts on dental caries: consequences for bucal health care. Caries Res. 38, 182–191. (2004).

Jiang, W. et al. .Pyrosequencing analysis of bucal microbiota shifting in various caries states in childhood. Microb. Ecol. 67, 962–969. (2014).

Ma, J.K. .Characterization of a recombinant plant monoclonalsecretory antibody and preventive immunotherapy in human. Nat. Med. 4, 601–606. (1998).

Mira, A. Horizontal gene transfer in bucal bacteria. In Bucal Molecular Microbiology (Rogers, A.H., ed.), pp. 65–86, Horizon Scientific Press. (2007).

Wright, C.J. et al. Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors. Mol. Bucal Microbiol. 29, 185–193. (2014).

Takahashi, N. and Nyvad, B. The role of bacteria in the caries process: ecological perspectives. J Dent. Res. 90, 294–303. (2011).

Takahashi, N. et al. Metabolomics of supragingival plaque and bucal bacteria. J. Dent. Res. 89, 1383–1388. (2010).






Review Articles

Most read articles by the same author(s)